Topic

Fasting & Metabolism

Your cells have a growth mode and a repair mode, and food is the main switch between them. Here we trace fasting, autophagy, mTOR and insulin from the hype down to what the studies in humans actually show.

Guide · Fasting & Metabolism

How long do you have to fast for autophagy? The honest answer

Sixteen hours. Twenty-four. Seventy-two. Everyone online seems to know exactly when your cells start cleaning house. The surprising truth: in humans, nobody does. Here's what the evidence actually supports.

5 min readUpdated Nov 9, 2026
Fasting & Metabolism

Does coffee break a fast? It depends what you're fasting for

The internet is split: "black coffee is fine" versus "anything but water breaks it". Both are half right, because "breaking a fast" means different things depending on why you're fasting.

3 min readUpdated Nov 9, 2026
Fasting & Metabolism

Early signs of insulin resistance, and what comes before them

By the time your blood sugar test looks bad, the problem has often been building for a decade. Insulin resistance is quiet, common and, caught early, very reversible.

4 min readUpdated Nov 9, 2026
Fasting & Metabolism

The fasting mimicking diet: does it work?

Five days a month of a special low-calorie diet, designed to trick your body into thinking it's fasting. The early human results are genuinely interesting. So are the fine print and the business behind it.

4 min readUpdated Nov 9, 2026
Fasting & Metabolism

mTOR and aging: the growth switch you want on, and off

Turning one cellular switch down made mice live longer, even when treatment began late in life. So why isn't everyone trying to switch it off? Because the same switch builds your muscles.

4 min readUpdated Nov 9, 2026
Fasting & Metabolism

Berberine vs metformin: what the evidence actually says

One is a cheap plant extract sold as "nature's Ozempic". The other is a decades-old diabetes drug that longevity fans take off-label. The comparison is more surprising than either side admits.

4 min readUpdated Nov 9, 2026
Fasting & Metabolism

Does intermittent fasting slow aging? What the trials say

In mice and monkeys, eating less extends life. Intermittent fasting promised the same benefits without counting calories. When scientists tested it in people, the results told a more interesting story.

4 min readUpdated Nov 9, 2026